Description
A sulfonamide antibiotic; inhibits recombinant P. carinii DHPS (IC50 = 25 nM) in a cell-free assay; active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay; active against C. spiroforme isolates from rabbits (MIC90 = 256 µg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 µg/ml); efficacious S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice (CD50s = 79.7, 2.7, and 12.2 mg/kg, respectively); efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg)